Mita haque biography of michael jordan
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Abstract
Interleukin (IL)-11, a multifunctional cytokine, contributes to numerous biological processes, including adipogenesis, hematopoiesis, and inflammation. Asthma, a respiratory disease, is notably characterized by reversible airway obstruction, persistent lung inflammation, and airway hyperresponsiveness (AHR). Nasal insufflation of IL-11 causes AHR in wild-type mice while lung inflammation induced by antigen sensitization and challenge, which mimics features of atopic asthma in humans, is attenuated in mice genetically deficient in IL-11 receptor subunit α-1 (IL-11Rα1-deficient mice), a transmembrane receptor that is required conjointly with glycoprotein 130 to transduce IL-11 signaling. Nevertheless, the contribution of IL-11Rα1 to characteristics of nonatopic asthma is unknown. Thus, based on the aforementioned observations, we hypothesized that genetic deficiency of IL-11Rα1 attenuates lung inflammation and increases airway responsiveness after acute inhalation exposure to ozone (O3), a criteria pollutant and nonatopic asthma stimulus. Accordingly, 4 and/or 24 h after cessation of exposure to filtered room air or O3, we assessed lung inflammation and airway responsiveness in wild-type and IL-11Rα1-deficient mice. With the exception of bronchoalveolar lavage macr
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Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases : subgroup analyses of the RESTART randomised, open-label trial
Al-Shahi Salman, Rustam; Minks, David P.; Mitra, Dipayan; Rodrigues, Mark A.; Bhatnagar, Priya; du Plessis, Johann C.; Joshi, Yogish; Dennis, Martin S.; Murray, Gordon D.; Newby, David E.; Sandercock, Peter A.G.; Sprigg, Nikola; Stephen, Jacqueline; Sudlow, Cathie L.M.; Werring, David J.; Whiteley, William; Wardlaw, Joanna M.; White, Philip M.; Baigent, Colin; Lasserson, Daniel; Sullivan, Frank; Carrie, Johanna; Rojas, Javier; Amoils, Shannon; Bamford, John; Armitage, Jane; Rinkel, Gabriel; Lowe, Gordon; Emberson, Jonathan; Innes, Karen; Dinsmore, Lynn; Drever, Jonathan; Williams, Carol; Perry, David; McGill, Connor; Buchanan, David; Walker, Allan; Hutchison, Aidan; Matthews, Christopher; Fraser, Ruth; McGrath, Aileen; Deary, Ann; Anderson, Rosemary; Walker, Pauli; Hansen, Christian; Parker, Richard; Rodriguez, Aryelly; Macleod, Malcolm; Gattringer, Thomas; Palmer, Jeb; Sakka, Eleni; Adil-Smith, Jennifer; Minks, David; du Plessis, Johannes; Lerpiniere, Christine; O'Brien, Richard; Burgess, Seona; Mead, Gillian; Paulton, Ruth; Doubal, Fergus; McCormick, Katrina; Hunter, Neil;
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